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A staff profile photo of Professor Thomas A Hughes

Professor Thomas A Hughes

Professor of Biosciences

School of Science, Technology and Health

Postgraduate Research Supervisor

Contact details

My research

For a full collection of my research to date, please visit my RaY profile.

View my full RaY profile

I am an academic cancer biologist with an extensive record of leading research in biomedicine, focusing on the molecular biology of cancers.

I have published over 80 peer-reviewed articles and my group has held more than £4M of research funding. I am a highly-experienced reviewer, editor, and panel-member for grant/paper review. I have also acted widely within and outside the UK as an external examiner for taught courses and doctoral degrees. I regularly communicate my work to a variety of scientific and lay audiences through seminars and public lecturers.

I have extensive experience in developing and leading Masters-level programmes and modules within cellular and molecular medicine. I contribute to a number of undergraduate modules within biomedicine at York St John.

I have supervised 27 successful doctoral research students, and numerous student projects for undergraduate or Masters programmes.

The aim of my research is to increase understanding of the biology of cancers with a view to using these new insights to improve cancer outcomes.

Particular research strengths are regulation of gene expression, roles of the tumour microenvironment, use and identification of cancer biomarkers and targets, and investigation of novel therapies.

My work involves close collaboration with NHS staff, including surgeons, oncologists, radiologists, pathologists and immunologists. This underpins my research by allowing access to clinical tissue and data, and translational of findings into the clinic. I also collaborate closely with engineers and chemists on the development of nanomedicine approaches for drug delivery and novel therapeutics.

Full lists of my publications can be found at my Google Scholar page or my ORCID page.

Recent publications

I am a Council member and Vice Chair of the Yorkshire Philosophical Society.

I am Deputy Chair of the Humber and North Yorkshire Cancer Research Collaborative.

I am Chair of the Leeds Neuro-oncology tissue bank.

I am a member of various clinical trial steering or tissue access committees.